Transfer of the immunologically competent T-lymphocytes from a donor into host expression different MHC antigens can have severe consequences, causing a fatal syndrome known as graft versus host disease (GVH). The following table explores a ran model of GVH, it displays the minimum number of parental strain t- cells which cause fatal GVH in sevearl treatment groups of F1 hybrid off spring derived from mating of two MHC different strain, a and b.
Minimum number of A or B strain t- cells which cause lethal GVH in the AxB F1 106
Group
(A X B) F1 hosts age and treatment
Strain A T cells
Strain B t cells
1
Intreated new born F1
5
5
2
Untreated adult f1
1000
1000
3
Adult F1 given 300 rad irradiation or an anti – proliferative drug
5
5
4
Adult F1 immunized with 10 of the strain parental t – cells and then irradiated as in group 3
1000
5
5
Adult F1 immunized with 107 a strain t- cells taken from donors that had previously been made tolerant to MHC of B, and then irradiated as in group 3.
5
5
Give a mechanistic explanation for finding which is consistent with all the data. Describe your answer with reasoning.
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