The Molecular of Tumorigenesis and Metastasis Describe the Warburg effect and its relevance to cancer (~300 words, 20% of marks). 2) Discuss the different lines of evidence suggesting that metabolic reprogramming is a new cancer cell hallmark. In your answer, try to cite as much use of the primary literature as possible and include at-least one diagram drawn by yourself for illustrative purposes (~1,500 words, 80% of marks). See: MED6040 Lecture 8: Genetic and Phenotypic Hallmarks of Cancer II References: Koppenol et al., (2011) Nature Reviews Cancer 11, 325-327 Ward and Thompson (2012) Cancer Cell 21, 207-308 Prensner and Chinnalyan (2011) Nature Medicine 17, 291 AND Primary Literature cited within. Also, please consult recent publications in this area, this includes 2012 and 2013.
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