The Contents-Inflammatory markersInflammatory markers can be used to detect the inflammation and as indicator for disease. Inflammatory markers include : C reactive protein (CRP), Cytokines (IL2, IL4, IL6, IL8, IL10, IL1,VEGF,IFN,TNF,MCP1,EGF), Adhesion Molecules (ICAM,VCAM,E-Selectin, L-Selectin, P-Selectin (Watson et al, 2012; Cesari et al,2003; Libby et al., 2014; Bautista et al., 2005 ).-The important of cytokines to be in normal range levelCytokines are a group of signalling molecules involved in communication between immune cells (Hamblin, 1993). Editing need please.-The important of cytokines in healthCytokines play important roles not in tissue homeostasis and the pathogenesis of many infectious diseases. Cytokines play a roles in the maintenance tissue homeostasis process, which requires a delicate balance between anabolic and catabolic activities, such as growth factors. They play important roles in modulating the proliferation of cells. However, excessive production of cytokines in inflamed periodontal tissues is responsible for the progress of periodontitis and periodontal tissue destruction. Particularly, inflammatory cytokines-such as IL-la, 1L-1, IL-6, and IL-8-are present in the diseased periodontal tissues, and their unrestricted production seems to play a role in chronic leukocyte recruitment and tissue destruction. Detecting and monitoring the cytokine level may allow us to diagnose the disease such as diabetes and obesity (Okada,1998).