Cell cycle checkpoints are an important feature of a dividing cell to reduce errors that can occur in various stages of the cell cycle. Loss of Rb, an important part of the G1-S transition checkpoint, can result in uncontrolled cell cycle progression and cancer. All of the following would mimic loss of Rb except:
Constitutively active G1-CDK
Constitutively active ERK
Constitutively active E2F
Constitutively active Myc
Constitutively active Ras GTPase activating protein
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