signalling process

Part A
Briefly discuss the signalling process which occurs when salmeterol binds to its target
receptor.
To answer this question you may describe the receptor which salmeterol binds to,
the signal transduction process which occurs when this receptor is activated and
molecular reasons which can explain the particular time of onset of action of
salmeterol when compared to other drugs of its class.
Your answer should be about two full pages of printed text, at 12 point and 1.5 line
spacing, or equivalent. This does not include figures, tables and references.
Part B:
Beta adrenergic blockers
Propranolol
Sotalol
Metoprolol
For these 3 drugs:
1) compare and contrast the pharmacokinetic parameters of these 3 drugs i.e.
a) absorption
b) distribution
c) metabolism
d) elimination
2) discuss how the pharmacokinetics of these 3 drugs are related to the
recommended dosage regimens
3) compare and contrast the side effect profiles of these drugs and how this can be
used in the selection of appropriate drug in this class for an individual patient
Your answer should not exceed three full pages of printed text, at 12 point and 1.5
line spacing, or equivalent. This does not include figures, tables and references.