1.    The Drug Discovery company has developed a compound X that binds and activates TSH receptors with a very high affinity.  A 30 year-old XY subject that has been taking very high daily doses of the compound X for 3 weeks would have which of the following blood profiles?

a. above normal TSH: above-normal thyroxine

a. above normal TSH: above-normal thyroxine

c. below normal TSH: above-normal thyroxine

d. below normal TSH: below-normal thyroxine

e. normal TSH: normal thyroxine

2.  Three weeks after a severe hemorrhage that caused a blood clot that totally blocked the hypothalamic-pituitary portal vessel, a 30 year-old XY subject would have:

a. lower plasma levels of oxytocin than those prior to the hemorrhage.

b. higher plasma levels of ACTH than those prior to the hemorrhage.

c. higher plasma levels of ADH than those prior to the hemorrhage.

d. lower plasma levels of LH than those prior to the hemorrhage.

e. higher plasma levels of TSH than those prior to the hemorrhage.

3.  Loss-of-function mutations of which of the following enzymes would be responsible for the presence of labia in a XY subject at birth?

a. P450scc

b. tyrosine hydroxylase

c. aromatase

d. 5?-reductase

e. PNMT

4.  Which hormone amongst the following has the shortest half-life in the plasma?

a. Aldosterone

b. Estradiol

c. Epinephrine

d. Thyroxine

e. Growth Hormone

5.  Insulin:

a. inhibits the activity of lipoprotein lipase.

b. stimulates the rate of gluconeogenesis.

c. normally increases plasma ketones.

d. increases the activity of glucokinase in hepatocytes.

e. facilitates translocation of GLUT2 in adipocytes.

6.     Mona has developed recent episodes of polyuria and polydipsia.   The lab analysis of her blood shows undetectable levels of c-peptide.   Which of the following could explain Mona’s condition?

a. Type II diabetes mellitus.

b. Type I diabetes mellitus.

c. Insulinoma (insulin-secreting tumor).

d. Congenital Adrenal Hyperplasia.

e. AIDison’s Disease

7.  John, a 20 year old college student, presented a normal history of health except a short statue.  John was at a height comparable to his peers’ until he reached 16 years of age.  Since then, it appears that his peers rapidly grew at a rate of 2 inches a year while John sluggishly grew at the rate of 0.2 inches a year.   John’s condition may be explained by a:

a. congenital growth hormone receptor defect.

b. LH-secreting pituitary tumor.

c. aromatase deficiency.

d. prolactin-secreting tumor.

e. 5-alpha reductase deficiency.

8.    The anterior pituitary gland secretes:

a. GnRH: ACTH: Prolactin

b. GH: CRH: LH

c. FSH: CRH: Prolactin

d. TSH: ACTH: ADH

e. TSH: LH: ACTH

f. ACTH: Prolactin: Oxytocin

g. TRH: ACTH: GH

9.     Rick, a 30-year old XY subject, was in a car accident three weeks ago.  Although Rick got a blunt hit to his sides, he did not feel that he needed to be taken to an ER.  Instead, he took a week of rest at home.   But, when he returned to work, he started feeling week, developed salt-craving and patches of darkness in the skin, and began to faint.  Rick’s doctor suspected these symptoms to Blunt force-induced Adrenal Insufficiency.  Rick’s hormonal profiles are likely to show ______ plasma aldosterone, _____ plasma cortisol,  and ______ plasma ACTH.

a. normal: normal: normal

b. below-normal: below-normal: above-normal

c. above-normal: above-normal: above-normal

d. normal: below-normal: above-normal

e. below-normal: below-normal: below-normal

f.  below-normal: normal: above-normal

g. above-normal: below-normal: below-normal