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Parkinson’s disease (PD) is a common heterogeneous neurodegenerative disorder in elder…

Background: Parkinson’s disease (PD) is a common heterogeneous neurodegenerative disorder in elder population.

Parkinson’s disease dementia (PDD) is one of the most common non-motor manifestations in PD patients.

No comprehensive review has been conducted to assess risk factors for PDD.

Methods: A systemic search for studies on PDD risk factors was performed. Cohort and case–control studies

that clearly defined PDD and presented relevant data were included. The data were analyzed to generate a

pooled effect size and 95 % confidence interval (CI). Publication bias was assessed using the Egger’s test and

the Begg’s test.

Results: A systematic search was conducted and yielded 5195 articles. After screening, 25 studies were included in the

current analysis. Development of PDD was positively associated with age (odds ratio [OR] 1.07, 95 % CI 1.03-1.13), male

(OR 1.33, 95 % CI 1.08-1.64), higher Unified Parkinson’s Disease Rating Scale (UPDRS) part III scores (relative risk [RR] 1.04,

95 % CI 1.01-1.07), hallucination (OR 2.47, 95 % CI 1.36-4.47), REM sleep behavior disorder (RBD) (OR 8.38, 95 % CI

3.87-18.08), smoking (ever vs. never) (RR 1.93, 95 % CI 1.15-3.26) and hypertension (OR 1.57, 95 % CI 1.11-2.22).

An inverse association was found between education (RR 0.94, 95 % CI 0.91-0.98) and PDD. Other reported factors,

including age of onset, disease duration of PD, Hoehn and Yahr stage and diabetes mellitus were not significantly

associated with PDD.

Conclusions: Advanced age, male, higher UPDRS III scores, hallucination, RBD, smoking and hypertension increase the

risk of PDD, whereas higher education is a protective factor for PDD.

Keywords: Parkinson’s disease, Dementia, Risk factors, Predictors
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4/28/2019 Mail – THESIS PROJECT THESIS PROJECT 1 message Hi , The requirement will be initially the whole literature search according to the databases i provided in the PPT and the table i provided in a form of flowchart and send me back to consult with my professor before we start the statistics. i want minimum 55-60 studies to be used for final stat.i am uploading the requirement in form of ppt and sample pdf ,the exclusion of the studies during literature search has to be applied according to paper like case report ,animal study etc etc cant be used . Any more doubts can get back to me for further clearance . i am here to help regarding the paper because its a very important project for me and i need to publish it . I can discuss the time limit according to the requirement of professor plus the literature search can be extensive and 1 month can be given to it. i am not in a hurry but looking for perfection . I am open for any discussion with the tutor regarding the title before starting the initial work . Thank you Dr Rajib Dutta Neurology Masters thesis . 2 attachments Can Vascular risk factors predict cognitive decline in PD PRESENTATION …..pptx 341K PDD-risk-XYQ.pdf 1005K… 1/1

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