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A review of “Dietary trehalose enhances virulence of epidemic Clostridium difficile.”

The article is a report on an experiment that describes how Dietary trehalose enhances the virulence of epidemic Clostridium difficile. To illustrate this, scientists analyze the whole-genome sequence of Clostridium difficile ribotype 027 (RT0270) strains show binary independent lineages arose in North America from the year 2000 to the year 2003. They also compared the historical, RT027 strains that revealed that both the epidemic lineages obtained a mutation in the gyrA gene, and this led to intensified resistance to antibiotics of fluoroquinolone. Conversely, the increased resistance to these antibiotics played a significant role in spreading of the stains of the RT027 and this resistance was observed in the nonepidemic Clostridium C ribotypes, and were able to identify the strains back in the mid-1980s. Therefore, other factors were responsible for the outbreak of the RT027 epidemic strains.

From the article, it is quite clear that dietary trehalose has played a role in spreading epidemic Clostridium difficile ribotypes. This is because both the strains; RT078 and RT027 were present before the outbreak of the epidemics. The strains were present even during the 1980s, but the outbreak was reported in the year 2003. From the experiments, the severity of disease by the RT027 strain metabolized the trehalose in the mouse model of the Clostridium difficile infection is entirely consistent with the intensified virulence in both the RT028 and the RT027 ribotypes as observed in various patients.

In conclusion, this study is essential since it details how dietary trehalose enhances virulence of epidemic Clostridium difficile. The ability to metabolize trehalose at relatively lower concentrations only shows the competitive advantage of growth in the existence of the intestinal community that is quite complex. The trehalose levels in the ileostomy fluid from patients that eat normal diets is quite high and is highly detected by the strains.