Grant application

70%- 6 pages 

ASSIGNMENT 2 

You are expected to write a research proposal for a two year project based around a topic assigned by your tutor based on a scientific paper (available on VLE) and your proposal should loosely build upon and extend the work described in that paper. Your proposal should address the following areas:

From this scientific paper DOI: 10.1158/0008-5472.CAN-18-0430 

1) What is your research question and hypothesis?
2) Relevant background information on the project area 

3) Why is your research important scientifically? What is its value to society? Identify the key beneficiaries and the ways in which they should benefit. 

4) Programme of your research, including milestones and tentative timeline, will constitute main basis for assessment. 

One approach is to define a set of 3-4 Objectives that you wish to complete, buit make sure that the Objectives are not so interdependent that if Objective 1 fails then you would not be able to undertake any further research……such a proposal would not be funded!! Structure your Programme of Work around these 3-4 Objectives, ideally using them as headings and explaining how you will achieve the experimental programme, what contingency factors you have considered in case of difficulties and what outcomes you expect. 

5) A brief statement on ethical considerations
6) Relevant references (usually not more than 20). 

Carefully proofread your proposal and pay attention to presentation and labelling of figures and tables. 

from this article (look at the uploaded file “gran applications”) HER2 Amplification in Tumors Activates PI3K/Akt Signaling Independent of HER3. 

i did not really come up with a clear question or hypothesis, 

at the uploaded slides, the aims I am trying to achieve (i just made tests and structured so the further research was seeing weather i could identify any homodimerisation and whether i could reduce the amount of HER2 protein present). 

in terms of research question still have not decided, you can come up with one from the article

DOI: 10.1158/0008-5472.CAN-18-0430

i did not really come up with a clear question or hypothesis, 

at the uploaded slides, the aims I am trying to achieve (i just made tests and structured so the further research was seeing weather i could identify any homodimerisation and whether i could reduce the amount of HER2 protein present). 

in terms of the research question still have not decided, you can come up with one from the article 

Please check the attached file: 

the grant application is the instruction of the assignments.

we should come up with a research question from the article in the file (Ruiz-saenze). 

the HER2 future directions file presentation slides done by me but still didn’t come up with a research question and i want you to help with that, please.

The proposal will be maximum of 6 A4     pages, font size Arial 11, 2 cm margins including the cover page as     stipulated on a proforma provided on VLE. 

Figures, tables and references should be     included within the main proposal as well as a chart/timetable for the     project duration of 2 years.