Sickle Cell Disease and Biocultural Evolution

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Question 1:Why is sickle cell anemia more common in certain regions of the world? What is the link between the sickle-cell, malaria and human alteration of the environment?

Question 2:Looking to the future, what factors (environmental, genetic, or social) could cause alteration in frequencies of the sickle cell in human populations? What changes to the sickle-cell allele do you envision as most likely, and why?

Instructions Explore sickle cell disease and its evolutionary basis in greater depth by reading information from the web sites below. Also, make sure to consult pages 317-320 of your textbook for a discussion of the topic.
Symptoms and Genetics of Sickle Cell Disease
http://ghr.nlm.nih.gov/condition/sickle-cell-disease

A Mutation Story (PBS Evolution Library)
http://www.pbs.org/wgbh/evolution/library/01/2/l_012_02.html

New York Times article on the evolution of the sickle cell allele

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