Suppose that you have been hired by university student health services to design a case-control study to assess the following hypothesis among undergraduate students
Suppose that you have been hired by university student health services to design a case-control study to assess the following hypothesis among undergraduate students:
Irregular sleep patterns increase the risk of headaches.Be sure that your design addresses the following elements:
Refine the study hypothesis so that it is as specific as possible and contains all elements of a “good” hypothesis.
How will you identify and define the cases?
Are there any exclusion criteria that you would apply?
How will you sample from the underlying population for your “controls”?
Who will you select as controls?
How will you select them?
How will you define the exposure of interest?
How will you collect the information on exposure?
What other information do you want to know about participants that may be related to the exposure of interest and/or the outcome (potential confounders)? Of these, what will you be able to collect and what will you be unable to collect?
Which measures of disease frequency and association will you calculate?
What are the strengths and limitations of your study?
Which limitations could be removed by using a different study design?
What other information would you like to know to design this study?
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