Enhanced Bioavailability of Buspirone  From Reservoir-Based Transdermal Therapeutic System, Optimization of Formulation Employing Box–Behnken Statistical  Design

Enhanced bioavailability of buspirone  from reservoir-based transdermal therapeutic system, optimization of formulation employing box–behnken statistical  design

• Introduction
• Materials and methods
• Materials
• Preparation of reservoir-based tts
• Experimental design
• Rheological measurements
• Determination of drug content
• Preparation of rat abdominal skin
• Determination of busp in skin layers
• Check point analysis and optimization model validation
• Stability studies
• Skin irritation studies
• In vivo bioavailability study in rabbits
• Pharmacokinetic analysis
• Statistical analysis
• Results
• Rheological measurements
• Drug content
• Formulation optimization by experimental design
• Stability studies
• Skin irritation study
• Discussion
• Fitting of data to the model
• Data analysis
• Contour plots and response surface analysis
• Optimization
• Validation of response surface methodology
• Conclusions
• References

In this work, the optimization of the buspirone trans-dermal therapeutic system was satisfactory and performed by Box-Behnken design. The response surface methodology and contour plot allowed finding the optimum conditions for TTS preparation. The results demonstrated that the formulation was nonirritating and did not cause any erythyma upon transdermal administration.