The allele that causes achondroplasia is a dominant mutation: 10 out of 102,246 births. Since this is a dominant mutation what is the frequency of the gene in newborns? The relative number of progeny from 110 acrondroplastic parents is 35, while 531 of their unaffected siblings had 740 progeny. Homozygous individuals for the acondroplastic allele die early in life. Given that the population is in mutation-selection balance, what mutation rate would lead to this frequency of the acrondroplastic allele?
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